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长QT综合征的胎儿心率预测因素
Jason L Mitchell1, Bettina F Cuneo, Susan P Etheridge
1The Heart Institute for Children, Hope Children's Hospital, 4440 W 95th Street, Oak Lawn, IL 60453, USA.
Circulation
|November 6, 2012
概括
胎儿长QT综合征 (LQTS) 经常与鼻肌梗塞有关,特别是当胎儿心率低于妊娠年龄的第三百分位时. 这一发现有助于在胎儿和家庭中诊断LQTS.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 胎儿医学 胎儿医学
背景情况:
- 胎儿长QT综合征 (LQTS) 已知会导致复杂的心律失常,如torsades de pointes和心房阻塞.
- 鼻肌梗塞也与胎儿的LQTS有关,但其特征仍然不太清楚.
研究的目的:
- 在被诊断为长QT综合征 (LQTS) 的胎儿中描述胎儿心率 (FHR) 和妊娠年龄 (GA) 概况.
主要方法:
- 胎儿LQTS病例通过家族病史或胎儿心律失常转诊来确定.
- 胎儿心率 (FHR) 的LQTS受试者与正常胎儿相比较.
- 为了确定LQTS FHR记录的百分比低于110bpm或GA的第三百分位数,计算了胸指数.
主要成果:
- 在42名LQTS受试者中,66%的FHR低于GA的第三百分位,相比之下,只有15%的FHR低于110bpm.
- 十个患有复杂心律失常的胎儿在整个妊娠期间也出现了严重的持续性鼻肌梗塞.
- 通过胎儿心律失常转诊诊断一个试验对象,导致在9个以前不被怀疑的家庭成员中确定LQTS.
结论:
- 胎儿心率 (FHR) 模式在正常胎儿和LQTS胎儿之间有所不同,并且根据妊娠年龄 (GA) 变化.
- 产后评估新生儿的FHR低于GA的第三百分位,可以提高对胎儿,新生儿及其家庭成员的LQTS检测.
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