将心血管会议摘要转化为出版物
Emil L Fosbøl1, Philip L Fosbøl, Robert A Harrington
1Duke Clinical Research Institute, Durham, NC 27705, USA. emil.fosbol@duke.edu
Circulation
|November 6, 2012
概括
不到一半的心血管会议摘要在五年内发表. 需要努力改进科学发现的转化为临床实践,以更快地传播知识.
科学领域:
- 心血管科学 心血管科学
- 医学研究传播 医学研究传播
背景情况:
- 科学发现转化为临床实践往往是缓慢的.
- 了解主要心血管会议摘要的出版率和及时性对于知识翻译至关重要.
研究的目的:
- 系统地评估主要心血管会议上提交的科学摘要的出版率,时间和相关性.
- 为了比较美国心脏协会 (AHA),美国心脏病学会 (ACC) 和欧洲心脏病学会 (ESC) 会议之间的出版结果.
主要方法:
- 一个自动化算法搜索了ISI科学网络,寻找发表在AHA,ACC和ESC科学会议 (2006-2008) 上的摘要.
- 使用多变量逻辑回归来比较出版率和期刊影响因素.
- 在分析中对抽象特征和原产国进行了调整.
主要成果:
- 总体而言,30.6%的摘要在2年内发表,在5年内增加到49.7% (AHA),42.6% (ACC) 和37.6% (ESC).
- 经过调整后,AHA会议的摘要显示,与ACC和ESC相比,其出版可能性更高.
- 基础科学摘要的出版率高于临床或人口科学摘要.
结论:
- 只有大约三分之一的摘要在两年内发表,不到一半在五年内发表.
- 在主要的心血管会议中,出版率存在显著差异.
- 进一步的研究和干预是必要的,以克服障碍,加快科学发现的传播到临床实践.
相关概念视频
01:34Crossing Over
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
02:03Anatomy of the Circulatory System
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
01:27Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
01:13The Cardiac Cycle
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...
01:29Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.