在非脊椎动物带状动物中识别了基本的神经
Philip Barron Abitua1, Eileen Wagner, Ignacio A Navarrete
1Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Nature
|November 9, 2012
概括
神经,对于脊椎动物头部进化至关重要,具有古老的起源. 研究人员在衣动物中发现了一种类似的细胞类型,可以重新编程成为这种细胞类型.
科学领域:
- 发育生物学是发展生物学.
- 进化发育生物学 进化发育生物学
- 编排进化的时间表.
背景情况:
- 神经是一个定义脊椎动物的创新,有助于头部的复杂性和转向主动掠食.
- 神经的进化起源仍然不清楚,因为在非脊椎动物中缺乏同类细胞类型.
研究的目的:
- 为了研究神经的进化起源.
- 在非脊椎动物带动物中识别潜在的同源细胞类型.
主要方法:
- 对西奥纳肠道 (Ciona intestinalis) 的衣进行分析.
- 在头皮黑色细胞血统中对Twist基因的向错误表达 (a9.49).
主要成果:
- 穿着连衣的Ciona intestinalis具有头部黑色细胞血统 (a9.49),与神经细胞有相似之处.
- 在这个血统中,Twist的错误表达将细胞重新编程成迁移的"ectomesenchyme".
- 这些发现表明神经的黑色素细胞调节网络早于脊椎动物和形动物的分歧.
结论:
- 神经调节网络可能早于衣动物和脊椎动物的分化.
- 像Twist这样的介质基因决定因素的合并到神经板外皮中对于脊椎动物"新头"的进化至关重要.
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