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Updated: May 16, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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在氨基催化区域选择性 [4 + 2] 循环添加 β 置换循环和多重合马隆尼特里尔中的立体分离

Xin Feng1, Zhi Zhou, Rong Zhou

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.

Journal of the American Chemical Society
|November 16, 2012
PubMed
概括

主要氨基酸催化循环乙烯的可切换反应. 根据基质,发生迈克尔添加或 [4 + 2] 循环添加,产生具有高选择性的复杂双循环结构.

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

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