代谢的循环天气拓
1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. j-bass@northwestern.edu
Nature
|November 16, 2012
概括
生物钟是基因编程的日常节奏,对生命至关重要. 了解这些生物振荡器有助于分析它们在健康和疾病中的作用.
科学领域:
- 时间生物学 时间生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 生物钟是与地球自转同步的内生振荡器.
- 这些时钟调节 prokaryotes 和多细胞生物的重要功能,影响睡眠,新陈代谢和养模式.
- 它们与地球物理时间和分子机制的联系使它们成为一个迷人的研究领域.
研究的目的:
- 探索生物钟作为基因编码振荡器的基本性质.
- 突出生物钟在不同生命形式和生理过程中的广泛影响.
- 强调研究健康和疾病时钟功能的工具的可用性.
主要方法:
- 对昼夜振荡器遗传编码的分析.
- 检查中央神经系统和外围组织中的时钟表达.
- 利用细胞和分子工具研究时钟机制.
主要成果:
- 生物钟使生物体能够预测与地球自转相关的环境变化.
- 时钟功能对于 prokaryotes 的健康和生长至关重要.
- 在多细胞生物中,时钟调节睡眠和新陈代谢等关键生理过程.
结论:
- 生物钟是基本的遗传振荡器,对生物体的健康和生理有深远的影响.
- 生物钟的研究提供了关于分子水平上健康和疾病的见解.
- 现在先进的工具允许对生物钟功能进行详细的分析.
相关概念视频
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Overview of Metabolism
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Regulation of Metabolism
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Introduction to Metabolism
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...

