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多能性重编程因子与基因组初始接触的促进者和阻碍者

Abdenour Soufi1, Greg Donahue, Kenneth S Zaret

  • 1Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine, University of Pennsylvania, Building 421, Rooms 131-132, 3400 Civic Center Boulevard, Philadelphia, PA 19104-5157, USA.

Cell
|November 20, 2012
PubMed
概括

转录因子Oct4,Sox2,Klf4和c-Myc (OSKM) 重新编程细胞. 最初的OSKM与基因组结合受到抑制色素的限制,但先驱因素Oct4,Sox2和Klf4促进了重新编程.

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