多功能纳米粒子:增加准和成像能力的成本与益处
Zhiliang Cheng1, Ajlan Al Zaki, James Z Hui
1Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104, USA.
Science (New York, N.Y.)
|November 20, 2012
概括
多功能纳米粒子增强了药物输送,但增加了复杂性和成本. 本综述探讨了添加高级功能和纳米粒子开发的实际挑战之间的权衡.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 基于纳米粒子的药物输送系统旨在提高治疗效率并降低药物毒性.
- 虽然批准的纳米粒子减少了毒性,但临床结果的改善是不一致的.
- 这推动了具有额外能力的多功能纳米粒子的开发.
研究的目的:
- 审查基于纳米粒子的药物输送的不断变化的格局.
- 分析多功能纳米粒子的优缺点.
- 讨论关于纳米粒子设计中的功能性与复杂性的持续辩论.
主要方法:
- 对纳米粒子药物输送系统的文献综述.
- 对批准纳米颗粒的临床结果和毒性数据的分析.
- 评估合成策略和多功能纳米粒子的体内行为.
- 对先进纳米粒子系统的监管考虑的讨论.
主要成果:
- 纳米粒子有效降低药物毒性,但并不总是改善临床结果.
- 多功能纳米粒子提供了增强的能力,如准和成像.
- 增加的功能与更大的合成复杂性,更高的成本和更复杂的体内行为有关.
- 复杂纳米颗粒的监管途径存在重大挑战.
结论:
- 纳米颗粒药物输送系统的开发需要平衡增强功能与实际复杂性.
- 多功能纳米粒子在药物输送方面是一个有希望但具有挑战性的前沿.
- 需要进一步的研究和战略开发,以优化复杂的纳米粒子系统的临床转化.
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