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艾滋病毒-1逆转录酶与皮科莫尔抑制剂的晶体结构揭示了药物设计的关键相互作用

Kathleen M Frey1, Mariela Bollini, Andrea C Mislak

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Journal of the American Chemical Society
|November 21, 2012
PubMed
概括

对与HIV-1逆转录酶的甲基醇复合物的结构分析揭示了关键的相互作用. 这些发现阐明了强大的抗病毒活性的起源,并为新型HIV-1抑制剂的设计提供了信息.

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