在嗅觉电路中,分组的神经元之间的非突触抑制
Chih-Ying Su1, Karen Menuz, Johannes Reisert
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Nature
|November 23, 2012
概括
果中的分隔嗅受体神经元 (ORNs) 直接通信,其中一个神经元的暂时激活会抑制邻近的神经元. 这种侧向抑制,可能是通过触觉合,影响嗅觉行为,可能编码突出.
科学领域:
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
- 昆虫生理学 昆虫生理学
背景情况:
- 感官器官表现出分隔,但其功能意义尚不清楚.
- 在Drosophila中,嗅觉受体神经元 (ORN) 是分隔的.
- 之前还没有证明ORN之间的直接通信.
研究的目的:
- 调查分隔ORN之间的直接通信.
- 阐明ORN之间侧面相互作用的机制和功能影响.
- 探索周边嗅觉抑制的流行和应用.
主要方法:
- 来自Drosophila ORNs的电生理学记录.
- 行为测试以评估嗅觉反应.
- 对于Anopheles CO(2) 敏感的ORN进行调查.
主要成果:
- 分隔的Drosophila ORNs通过横向抑制直接进行通信.
- 一个ORN的暂时激活会抑制邻近ORN的持续反应.
- 这种抑制是独立于突触的,很可能是通过触觉合介导的.
- 周围侧向抑制调节嗅觉行为.
- 在对Anopheles CO(2) 敏感的ORN中观察到类似的抑制.
结论:
- 嗅觉信息集成是通过ORN之间的侧面相互作用发生的.
- 侧向抑制可以通过对比持续和短暂的反应来编码感官突出.
- 周边侧向抑制在昆虫中很普遍,在害虫控制中具有潜在的应用.
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