一个在癌症战争中失去的调解员
1Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA. x4guo@ucsd.edu
Cell
|November 27, 2012
概括
通过激活转化生长因子β (TGF-b) 信号传导,中介子单元MED12的丢失意外导致抗癌药物耐药性. 抑制TGF-b使癌细胞重新敏感,提供了一种新的组合疗法策略.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 细胞信号传递 细胞信号传递
背景情况:
- 中介体复合体对于转录调节至关重要.
- 媒体12是"调解者"综合体的一个关键子单位.
- 耐药性仍然是癌症治疗的一个主要挑战.
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