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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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在折叠块共聚合物中的直角自组装.

Nobuhiko Hosono1, Martijn A J Gillissen, Yuanchao Li

  • 1Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Journal of the American Chemical Society
|November 28, 2012
PubMed
概括

研究人员创建了ABAtriblock共聚合物,这些共聚合物折叠成单链聚合物纳米粒子 (SCPNs),使用-1,3,5-三胺 (BTA) 和2-ureaidopyrimidinone (UPy) 主题的正交自组装用于分隔纳米结构.

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科学领域:

  • 聚合物化学 聚合物化学
  • 超分子化学 超分子化学
  • 纳米技术纳米技术

背景情况:

  • 亚巴三块式共聚合物为创建复杂的宏分子架构提供了一个多功能平台.
  • 正角自组装可精确控制聚合物折叠和纳米结构的形成.
  • 单链聚合物纳米粒子 (SCPNs) 由于其独特的特性,对各种应用具有前景.

研究的目的:

  • 为了合成和表征ABA三环阻断共聚物,具有两个互补的联结基因.
  • 研究这些图案的直角自组合,以形成单链聚合物纳米粒子 (SCPN).
  • 为了证明分隔的SCPNs与明显的微域的形成.

主要方法:

  • 原子转移基聚合 (ATRP) 用于共聚合物合成.
  • 后功能化引入o-nitrobenzyl保护的2-ureidopyrimidinone (UPy) 和-1,3,5-三胺基 (BTA) 部分.
  • 两个步骤的热/光辐射处理,用于顺序自组装.
  • 可变温度NMR,循环二重化谱学,尺寸排除色谱学 (SEC),小角度X射线散射 (SAXS) 和原子力显微镜 (AFM) 用于表征.

主要成果:

  • 成功合成了具有UPy和BTA图案的ABAtriblock共聚合物.
  • 证明BTA (螺旋聚合物) 和UPy (二元体) 在顺序刺激 (降温和光照射) 时的直角,内分子自组合.
  • 分隔式SCPNs的形成,聚合物大小显著减少 (30-60%通过SEC观察到).
  • 在SCPN中,有明显的微域的证据,模仿蛋白质二次结构.

结论:

  • 在ABAtriblock共聚物中,互补基因的直角自组会导致分隔的SCPNs的形成.
  • 由于BTA和UPy自组装的顺序性和不干扰性,可以控制单链折叠.
  • 由此产生的SCPN具有分隔式内部,为需要不同的微环境的应用提供了潜力.