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Ca2+通过调节脂质的电荷特性来调节T细胞受体激活

Xiaoshan Shi1, Yunchen Bi, Wei Yang

  • 1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Nature
|December 4, 2012
PubMed
概括

离子 (Ca2+) 直接与阳离子脂结合,调节T细胞抗原受体-CD3复合体 (TCR) 功能. 这种Ca2+结合会从膜中释放CD3细胞质域,增强氨酸酸化和T细胞激活灵敏度.

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