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相关概念视频

Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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相关实验视频

Updated: May 16, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

在复杂的世界中建模转录组动态.

Philipp A Jaeger1, Colleen Doherty, Trey Ideker

  • 1Departments of Medicine and Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Cell
|December 11, 2012
PubMed
概括
此摘要是机器生成的。

科学家们现在可以预测由于环境因素导致的中的基因表达变化. 在模拟转录反应方面的这一突破为预测其他生物体在现实条件下的反应提供了潜力.

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

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Polysome Purification from Soybean Symbiotic Nodules
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Polysome Purification from Soybean Symbiotic Nodules

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相关实验视频

Last Updated: May 16, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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科学领域:

  • 基因组学就是基因组学.
  • 环境科学 环境科学
  • 植物生物学 植物生物学

背景情况:

  • 预测来自环境刺激的基因表达变化是一个复杂的挑战.
  • 了解这些反应对农业和生态至关重要.

研究的目的:

  • 开发一种模型,用于预测在不同环境条件下大米的全基因组mRNA表达变化.
  • 推进预测暴露在不受控制的环境中的生物体的转录反应的能力.

主要方法:

  • 使用先进的计算建模技术.
  • 分析了从米中获得的全基因组mRNA表达数据,这些米经历了各种环境刺激.

主要成果:

  • 在大米中成功模拟了全基因组的mRNA表达变化.
  • 证明了预测对环境变量转录反应的可行性.

结论:

  • 长野及其同事的工作在预测生物学方面取得了重大进展.
  • 这项研究有望预测现实世界的各种生物中的基因表达.