一个保存的专用嗅觉电路用于检测Drosophila中的有害微生物
Marcus C Stensmyr1, Hany K M Dweck, Abu Farhan
1Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, 07745 Jena, Germany. mstensmyr@ice.mpg.de
Cell
|December 11, 2012
概括
通过一种特定的气味来避免有毒的微生物,geosmin. 这种由地质素激活的嗅觉回路向不安全的食物发出信号,并阻碍了食和繁殖.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统是一种嗅觉系统.
- 动物行为 动物行为
背景情况:
- 需要安全的食物来源,通常在发酵的水果上酵母.
- 区分安全酵母和受微生物污染的酵母对于生存至关重要.
- 嗅觉系统在识别食物来源方面发挥着关键作用.
研究的目的:
- 识别用于检测有害微生物的嗅觉机制.
- 描述涉及感知微生物气味剂地球的神经电路.
- 了解地质矿物检测对行为的后果.
主要方法:
- 使用Drosophila melanogaster作为一个模型生物.
- 研究的嗅觉受体基因表达 (Or56a).
- 使用有针对性的激活和功能测试绘制神经通路.
主要成果:
- 发现了一种特定的嗅觉电路,该电路仅由地质矿物激活.
- 地质素激活表达Or56a的感觉神经元,准DA2球体.
- 激活DA2球体是足够的和必要的厌恶,抑制养和卵巢.
结论:
- 拥有专门的地质层检测系统,用于识别不合适的食物和繁殖场所.
- 这个系统提供了一种敏感和特定的机制,以避免微生物毒素.
- 地质素检测途径在Drosophila属中得到保护.
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