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哺乳动物的心脏通过先前存在的心肌细胞进行更新

Samuel E Senyo1, Matthew L Steinhauser, Christie L Pizzimenti

  • 1Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA.

Nature
|December 11, 2012
PubMed
概括

新的心脏细胞 (心肌细胞) 从现有的细胞中产生,而不是干细胞,通过分裂. 这种心肌细胞的替代在衰老过程中缓慢发生,并且在受伤部位附近增加.

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...