成年人的早产心脏:心血管磁共振显示左心室质量,几何和功能的明显差异
Adam J Lewandowski1, Daniel Augustine, Pablo Lamata
1Oxford Cardiovascular Clinical Research Facility, University of Oxford, Oxford, UK.
Circulation
|December 11, 2012
概括
过早分娩与成人心脏结构和功能的改变有关. 过早出生的个体表现出左心室质量增加和心和腹功能受损,突出显示了长期的心血管影响.
科学领域:
- 心脏病学 心脏病学
- 发育生物学 发展生物学
- 身体生理学 身体生理学
背景情况:
- 过早分娩在子宫中断左心室发育,可能导致不良的心脏重塑.
- 动物研究表明早产会对左心室的结构和功能产生不利影响.
- 这项研究调查了早产对人类的长期心血管影响.
研究的目的:
- 为了确定早产是否与成年后的左心室结构和功能有关.
- 量化早产和早产成年人之间的左心室质量,几何和心肌功能差异.
- 探索可能改变这些心血管参数的围产期因素.
主要方法:
- 心血管磁共振成像对234名成年人 (20-39岁) 进行.
- 102人有过早分娩史 (妊娠年龄为30.3±2.5周),132人出生时.
- 量化了左心室质量,使用计算心脏图谱的3D几何和心肌功能 (心缩和心缩).
主要成果:
- 过早出生的人与出生的人相比,左心室质量显著增加 (P<0.001).
- 在早产成年人中观察到明显的3D左心室几何形状,其特点是心室较短,顶部偏移.
- 在早产儿组 (P<0.001) 中发现纵向心和心功能,以及旋转运动显著减少 (P<0.001).
- 怀孕期间的孕前与后代的纵向心应变进一步减少有关 (P=0.02).
结论:
- 过早出生的成年人表现出左心室质量增加和心脏几何变化.
- 在早产的个体中,心肌缩和腹缩功能的显著缺陷持续到成年期.
- 这些发现强调了早产的长期心血管后果.
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