CCR5是Staphylococcus aureus白血病毒素ED的受体之一
Francis Alonzo1, Lina Kozhaya, Stephen A Rawlings
1Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA.
Nature
|December 14, 2012
概括
黄金葡萄球菌的白血病毒素ED (LukED) 通过与CCR5受体结合来向免疫细胞. 使用马拉维洛克等药物阻断CCR5,可以抑制黄金色细菌的毒性和感染.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 形成毛孔的毒素是细菌毒性的关键因素.
- 黄金葡萄球菌使用白血毒素杀死宿主细胞,特别是免疫细胞.
- 葡萄球菌白血病毒素的特定宿主点在很大程度上是未知的.
研究的目的:
- 为了确定主体因素决定白血素选择性.
- 为了调查所识别的因子在S. aureus病原发生中的作用.
- 探索针对这种相互作用的治疗策略.
主要方法:
- 基于细胞的测试以评估白血素细胞毒性.
- 使用遗传和生化方法识别宿主细胞受体.
- 在体内研究中,使用CCR5缺乏的小鼠和感染模型.
- 使用CCR5抗剂进行药理抑制.
主要成果:
- 艾滋病毒共受体CCR5被确定为S. aureus白血病毒素ED (LukED) 向髓状细胞和T淋巴细胞的关键决定因素.
- 包括艾滋病毒药物马拉维罗克在内的CCR5抗剂有效地阻断了LukED介导的细胞杀死.
- 缺乏CCR5的小鼠对致命的金黄色细菌感染表现出显著的抵抗力.
- 通过LukED介导的CCR5 (((+) 白细胞的枯竭代表了一种新的免疫规避策略.
结论:
- CCR5是一种细胞受体,被S. aureus LukED利用用于免疫细胞向.
- 准CCR5提供了一个潜在的治疗策略来对抗金杆菌感染.
- 了解这种相互作用揭示了细菌免疫逃避的新机制.
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