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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

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相关实验视频

Updated: May 16, 2026

Chromatin Isolation by RNA Purification (ChIRP)
11:09

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

通过长非编码RNAs进行表观遗传调节.

Jeannie T Lee1

  • 1Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02138, USA. lee@molbio.mgh.harvard.edu

Science (New York, N.Y.)
|December 15, 2012
PubMed
概括

哺乳动物基因组复杂,许多转录单元产生长非编码RNA (lncRNAs),重叠编码基因. 了解这些lncRNAs的多样性功能是分子生物学中的一个关键挑战.

科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 在RNA生物学,RNA生物学.

背景情况:

  • 最近的研究揭示了哺乳动物基因组中普遍和复杂的转录.
  • 许多转录单元,主要生产长非编码RNA (lncRNAs),重叠传统编码基因.
  • lncRNAs包括多种类型,包括反感,内基,基因间转录,伪基因和逆转移子.

研究的目的:

  • 探索大量 lncRNAs 的功能意义.
  • 调查 lncRNA 是否是功能分子或仅仅是转录副产品.
  • 提供一IncRNA功能和机制的新兴景观.

主要方法:

  • 关于哺乳动物基因组转录的最近研究的综述.
  • 对新兴长非编码RNA (lncRNA) 系统的分析.
  • 对 lncRNA 功能和机制进行比较检查.

主要成果:

  • 哺乳动物基因组的转录非常复杂, lncRNAs和编码基因之间存在广泛的重叠.
  • lncRNAs的功能和机制代表着一个多样化且在很大程度上未知的领域.
  • 很大一部分转录单元产生lncRNAs,挑战了它们仅仅是副产品的概念.

更多相关视频

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

相关实验视频

Last Updated: May 16, 2026

Chromatin Isolation by RNA Purification (ChIRP)
11:09

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

结论:

  • lncRNAs的功能作用是多种多样的,尚未完全理解.
  • 进一步的研究对于阐明 lncRNA 功能和机制的"狂野西部"景观至关重要.
  • 了解这些宏分子是未来分子生物学研究的关键挑战.