霍克斯基因通过控制图灵型机制的波长来调节数字模式
Rushikesh Sheth1, Luciano Marcon, M Félix Bastida
1Facultad de Medicina, Instituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas-Sociedad para el Desarrollo Regional de Cantabria-Universidad de Cantabria, 39011 Santander, Spain.
Science (New York, N.Y.)
|December 15, 2012
概括
鼠标遗传学揭示,远程霍克斯基因剂量影响了数字间距,支持图灵型反应-扩散模型用于四肢发育. 这种机制可能解释了五位数状态的演变.
科学领域:
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
- 计算生物学 计算生物学
背景情况:
- 重复的自然图案,如条纹,通常来自反应扩散系统 (图灵模型).
- 脊椎动物四肢的数字模式代表了数字/非数字形成的代模式.
研究的目的:
- 调查小鼠四肢中数字图案的基因机制.
- 为了确定反应-扩散原理是否适用于肢体发育.
主要方法:
- 利用小鼠遗传学分析了在Gli3-null背景下减少远端Hox基因 (Hoxa13,Hoxd11-Hoxd13) 的影响.
- 采用计算建模来模拟基于遗传数据的数字模式.
- 将小鼠的指纹图案与鱼翅内骨架图案进行比较.
主要成果:
- 远端霍克斯基因的逐渐减少导致了越来越严重的多爪 (额外的数字) 与更薄,密集的数字.
- 计算机建模支持一个图灵型机制,其中远端霍克斯基因剂量调节数字间距 (周期/波长).
- 观察到老鼠的手指图案和鱼骨图案之间的表型相似之处.
结论:
- 这项研究提供了证据,证明数字图案中的图灵型反应扩散机制.
- 远端霍克斯基因充当数字模式周期性的关键调节器.
- 五指形 (五位数) 肢体结构可能是从祖先的图灵型机制进化出来的.
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