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Updated: May 15, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
09:45

Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

全基因组检测单核酸和复制数变异的单个人类细胞

Chenghang Zong1, Sijia Lu, Alec R Chapman

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Science (New York, N.Y.)
|December 22, 2012
PubMed
概括

一种名为多重和循环式放大周期 (MALBAC) 的新方法可以改善单细胞的全基因组测序. 这种技术克服了放大偏差,使得高基因组覆盖率和精确检测遗传变异,如副本数变异和单核酸变异.

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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants09:16

Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

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Characterizing Mutational Load and Clonal Composition of Human Blood07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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Overview