混合河马和WNT:共享信使和监管
Becky P Tsai1, Nate P Hoverter, Marian L Waterman
1Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, CA 92697, USA.
Cell
|December 25, 2012
概括
这条Wnt路径劫持了Hippo信号组件. 新的研究表明TAZ介导Wnt信号,YAP1与TBX5形成复合体,揭示了新的Wnt通路机制.
科学领域:
- 细胞信号传递途径 细胞信号传递途径
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- Wnt通路对于胚胎发育和成年组织恒温至关重要.
- 河马通路通过控制细胞增殖和亡来调节器官大小.
- 异常的Wnt和Hippo信号与各种癌症有关.
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