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Updated: May 15, 2026

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants
07:44

An Electrochemiluminescence-Based Assay for MeCP2 Protein Variants

Published on: May 22, 2020

MeCP2与活性基因中富含的5hmC和神经系统中可访问的染色体结合

Marian Mellén1, Pinar Ayata, Scott Dewell

  • 1Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Cell
|December 25, 2012
PubMed
概括

在大脑中,5-甲基细胞蛋白 (5hmC) 和甲基-CpG结合蛋白2 (MeCP2) 调节基因表达不同于干细胞. MeCP2 结合了 5hmC 丰富的活性基因,突变影响了这种相互作用.

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