相关实验视频

Updated: May 11, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

多个与自闭症相关的基因通过突触支架PSD-95的蛋白质体降解来调解突触消除

Nien-Pei Tsai1, Julia R Wilkerson, Weirui Guo

  • 1Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|December 25, 2012
PubMed
概括

肌细胞增强因子2 (MEF2) 和脆弱X智障蛋白 (FMRP) 通过protocadherin 10 (Pcdh10) 控制突触消除. 这一途径涉及PSD-95降解,并且在FMRP缺乏的神经元中被破坏,突出显示了自闭症基因的作用.

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