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在人类tRNA合成酶上以ATP导向捕获生物活性草药

Huihao Zhou1, Litao Sun, Xiang-Lei Yang

  • 1The Skaggs Institute for Chemical Biology, Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Nature
|December 25, 2012
PubMed
概括

黄 (HF) 是人类prolyl-tRNA合成酶 (ProRS) 的一个依赖ATP的抑制剂. 结构显示HF模仿了普罗林和tRNA,同时结合ProRS上的两个位点.

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