一个I类抗原,HLA-G,表达在人类热囊细胞中
概括
人类基因相容性抗原HLA-Gα链有五种异型,主要存在于怀孕早期的细胞细胞体中. 它的表达是发育调节和细胞类型特定的,在孕期第三季度显著下降.
科学领域:
- 免疫遗传学 免疫遗传学
- 发展生物学 发展生物学
- 人类繁殖人类的繁殖.
背景情况:
- 人类组织相容性抗原HLA-G在怀孕期间对免疫耐受性起着至关重要的作用.
- 了解HLA-G表达模式对于生殖免疫学研究至关重要.
研究的目的:
- 为了描述HLA-Gαα链的异型.
- 研究人类胎盘组织和细胞系中HLA-G表达的细胞类型特异性和发育调节.
主要方法:
- 采用二维凝电泳来识别HLA-Gα链异型.
- 表达分析是在第一和第三个三个月的小细胞核细胞体和胆管癌细胞系 (JEG,Jar,BeWo) 上进行的.
主要成果:
- 鉴定出了HLA-Gα链的五种异型 (37至39千多).
- HLA-G在第一季度细胞otrophoblasts丰富,但在第三季度细胞otrophoblasts显著减少.
- 在JEG胆瘤细胞系中观察到HLA-G表达,但在Jar或BeWo细胞系中没有.
- 在细胞质体中没有检测到显著的等位基变异,这表明多态性有限.
结论:
- 在妊娠期间,HLA-G表达受到细胞类型和发育阶段的严格调节.
- 这种蛋白质在怀孕早期的细胞otrophoblasts中显著表达,这表明它在胎盘早期发育和免疫规避中发挥了作用.
- 进一步研究HLA-G在生殖免疫学中的功能是有必要的.
相关概念视频
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Presenting Cells
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...


