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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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用MDA5激活dRNA识别,线程形成和抗病毒信号的结构基础

Bin Wu1, Alys Peisley, Claire Richards

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|January 1, 2013
PubMed
概括

病毒RNA受体MDA5与RIG-I不同,它与内部双链RNA (dsRNA) 不同地结合. 这种结构揭示了MDA5如何在dsRNA上形成细丝,从而触发抗病毒免疫信号.

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