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小分子与DNA小沟的结合是由保存的水集群介导的

DengGuo Wei1, W David Wilson, Stephen Neidle

  • 1UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

Journal of the American Chemical Society
|January 2, 2013
PubMed
概括

在DNA小沟中保存的水集群稳定了小分子的结合. 这种水化网络与水化脊柱不同,对于连接体的定位至关重要,并解释了结合亲和关系.

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