长期使用阿司匹林和与年龄相关的黄斑变性
Barbara E K Klein1, Kerri P Howard, Ronald E Gangnon
1Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison 53726-2336, USA. kleinb@epi.ophth.wisc.edu
JAMA
|January 5, 2013
概括
长达10年的定期使用阿司匹林与与晚年相关的黄斑变性 (AMD) 风险的小幅增加有关. 然而,5年内使用阿司匹林与早期或晚期AMD发病率没有关联.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 心血管健康 心血管健康
背景情况:
- 阿司匹林通常用于缓解疼痛和心脏保护.
- 眼科医生对眼科手术前和与年龄相关的黄斑退行症 (AMD) 患者使用阿司匹林表示担忧.
研究的目的:
- 调查定期使用阿司匹林与与年龄相关的黄斑变性病 (AMD) 的发生率之间的联系.
主要方法:
- Beaver Dam眼睛研究是一项为期20年的基于人口的纵向研究,追踪了4926名年龄在43-86岁之间的参与者.
- 参与者报告经常使用阿司匹林 (≥2次/周>3个月).
- 早期和晚期AMD的发生率,包括新血管AMD和纯地理缩,通过视网膜照片进行评估.
主要成果:
- 在检查前10年定期使用阿司匹林与晚期AMD (HR, 1.63) 和特别是新血管AMD (HR, 2.20) 的风险增加有关.
- 在阿司匹林使用 (5或10年前) 与早期AMD发病率之间没有发现显著的关联.
- 在使用阿司匹林10年前,使用者的晚期AMD发病率估计为1.76%,而非使用者的发病率为1.03%.
结论:
- 在观察前10年定期使用阿司匹林与事件晚期和新血管AMD风险的统计学上显著增加有关,尽管很小.
- 在观察到发病前5年内使用阿司匹林与发生的早期或晚期AMD无关.
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