世界贸易中心暴露与过度癌症风险之间的关联
Jiehui Li1, James E Cone, Amy R Kahn
1NewYorkCityDepartmentof Health and Mental Hygiene, Long Island City, New York 11101, USA. jli3@health.nyc.gov
JAMA
|January 5, 2013
概括
这项研究发现,在世界贸易中心健康登记处的登记者中,前列腺癌,甲状腺癌和骨髓瘤的风险增加. 然而,这些发现是基于少数病例,并且没有发现暴露强度和癌症风险之间的联系.
科学领域:
- 环境流行病学环境流行病学
- 公共卫生监督是对公共卫生的监督.
- 癌症研究 癌症研究
背景情况:
- 2001年9月11日的恐怖袭击释放了致癌物质,引发了人们对癌症发病率增加的担忧.
- 世界贸易中心健康登记册是为了监测暴露个体的健康而建立的.
研究的目的:
- 为了评估在世界贸易中心健康登记册中注册的个体中癌症发病率.
- 评估世界贸易中心暴露强度与癌症发展之间的关系.
主要方法:
- 一项观察性研究对55778名纽约州居民进行了跟踪,这些居民在世界贸易中心健康登记册 (2003-2004) 登记,直到2008年12月31日.
- 癌症病例通过与州癌症登记处联系来确定,并计算标准化发病率 (SIR).
- 考克斯的比例危险模型评估了队列内的暴露-反应关系.
主要成果:
- 在2007-2008年,救援/恢复工作人员显示,与纽约州的比率相比,前列腺癌 (1.43),甲状腺癌 (2.02) 和多发性髓瘤 (2.85) 的SIRs显著升高.
- 对于整个队列或未参与救援/恢复的人群,没有观察到总体上升的癌症发病率.
- 队列内分析没有显示世界贸易中心暴露强度和特定癌症类型之间的显著关联.
结论:
- 2007-2008年,在与纽约州居民相比,在世界贸易中心健康登记处的入学者中观察到前列腺癌,甲状腺癌和骨髓瘤的风险过高.
- 然而,这些发现是基于少数癌症事件和多次比较.
- 需要进一步的长期跟踪,以调查与长期潜伏癌症和特定暴露相关风险的潜在联系.
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