相关实验视频
Updated: Aug 12, 2026

10:16
Accurate and Phenol Free DNA Sexing of Day 30 Porcine Embryos by PCR
Published on: February 14, 2016
由经过活检的人类植入前胚胎的怀孕,这些胚胎通过Y特异性DNA放大进行性别分化
A H Handyside1, E H Kontogianni, K Hardy
1Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Nature
|April 19, 1990
概括
植入前遗传诊断使得X相关疾病的性别选择成为可能. 这允许转移未受影响的胚胎,防止转移诸如上腺核胆固醇损伤和X关联智力障碍等遗传疾病.
科学领域:
- 遗传学 是一个遗传学.
- 生殖医学 生殖医学
- 分子生物学分子生物学
背景情况:
- 超过200种X相关的衰退性疾病影响男性.
- 产前诊断存在,但并不总是足够的.
- 替代方法包括胎儿性别确定和选择性堕胎.
研究的目的:
- 通过使用X相关疾病的植入前遗传诊断来确定怀孕.
- 为了使未受影响的胚胎在体外受精 (IVF) 后转移.
主要方法:
- 在体外受精 (IVF) 之后进行胚胎活检.
- 单细胞DNA放大用于Y染色体检测 (性别).
- 已确认的女性胚胎转移到子宫.
主要成果:
- 在两对有风险的夫妇中成功确定怀孕.
- 在这两种情况下都确认了正常的雌性双胞胎.
- 对于X相关遗传疾病的植入前性别选择的演示.
结论:
- 植入前遗传诊断是预防X相关遗传疾病的可行选择.
- 该技术允许选择未受影响的胚胎进行移植.
- 它为有 X 相关疾病传播风险的家庭提供了一种新的生殖策略.
关键词:
遗传学和生殖生殖学相关概念视频
Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
In Vitro Fertilization
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

