Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Gpnmb defines a phagocytic state of microglia linked to cell death in prion disease mouse model.

Nature communications·2026
Same author

Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.

Gut microbes·2026
Same author

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex.

PLoS pathogens·2026
Same author

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.

FEBS open bio·2026
Same author

Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies.

Molecular systems biology·2026
Same author

Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: May 15, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

微质:替罪羊,破坏者,还是其他什么?

Adriano Aguzzi1, Ben A Barres, Mariko L Bennett

  • 1Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8012 Zurich, Switzerland. adriano.aguzzi@usz.ch

Science (New York, N.Y.)
|January 12, 2013
PubMed
概括

微质,大脑的免疫细胞,防御神经退行性疾病,尽管经常被视为有害. 它们的功能障碍也可能导致缺乏明确的免疫链接的神经疾病.

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 微质细胞是位于中枢神经系统 (CNS) 中的主要免疫细胞.
  • 它们进行免疫监测,并对中枢神经系统损伤和疾病做出反应.
  • 微质激活传统上与神经毒性有关,但也起着保护作用.

研究的目的:

  • 探索微质在神经健康和疾病中的双重作用.
  • 研究微质功能障碍对神经系统疾病的贡献.

主要方法:

  • 审查关于中枢神经系统中微质功能现有文献.
  • 对研究各种神经疾病中微质反应的研究进行分析.

主要成果:

  • 在许多神经退行性疾病中,微质是关键的防御者.
  • 有证据表明,即使没有明显的免疫参与,微质功能障碍也可能是神经系统疾病的主要原因.

结论:

  • 微质在中枢神经系统中既具有神经保护作用,也具有潜在的致病作用.
  • 了解微质功能障碍对于诊断和治疗更广泛的神经系统疾病至关重要.

更多相关视频

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

相关实验视频

Last Updated: May 15, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014