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Updated: May 15, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

与β-arrestin-2招募或脂酶-C激活相关的明显的CCK-2受体构造,由偏向的对手揭示

Rémi Magnan1, Chantal Escrieut, Véronique Gigoux

  • 1EA 4552, Université de Toulouse 3, 31432 Toulouse, France.

Journal of the American Chemical Society
|January 18, 2013
PubMed
概括

七个跨膜受体 (7TMRs) 在结合时采用不同的结构,使药物设计具有偏见. 这项研究揭示了CCK2R形状的结构差异,这对于向的G蛋白或β-arrestin信号传递至关重要.

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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