慢性压力通过多巴胺感受神经元中的葡萄糖皮质体受体触发社会厌恶
Jacques Barik1, Fabio Marti, Carole Morel
1Molecular Genetics, Neurophysiology and Behavior Group, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 7224, Paris, France. jacques.barik@snv.jussieu.fr
概括
重复的压力会通过影响多巴胺通路引起社会厌恶. 特定多巴胺神经元中的葡萄糖皮质体受体是这种应激反应和社会行为变化的关键.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子生物学分子生物学
背景情况:
- 重复的创伤事件可能导致持久的行为变化,影响认知,情绪和社会功能.
- 动物的社会攻击导致社会厌恶和焦虑,与涉及葡萄皮质醇和多巴胺的压力反应有关.
- 在多巴胺系统中,葡萄糖皮质体受体 (GR) 在调解这些行为变化的确切作用尚未完全理解.
研究的目的:
- 调查多巴胺类神经元中葡萄糖皮质类受体 (GR) 在经历反复攻击后调解行为适应的特定作用.
- 为了确定多巴胺释放与多巴胺受体神经元中的GR是否对社会厌恶和焦虑产生不同影响.
- 阐明压力,葡萄糖皮质体受体和多巴胺系统在调节社会行为的关系.
主要方法:
- 在多巴胺通路中选择性失活葡萄糖皮质体受体 (GR) 基因的小鼠的生成.
- 将这些转基因小鼠和野生类型的对照暴露在反复的侵略性遭遇中 (社会失败).
- 评估社会行为 (社会厌恶),焦虑和恐惧记忆,以及对多巴胺系统的神经化学和电生理学分析.
主要成果:
- 在多巴胺感受神经元中选择性失活GR,但不是DA释放神经元,特别促进了社会厌恶和相关的多巴胺能神经适应.
- 焦虑和恐惧的记忆没有受到针对性GR失活的显著影响.
- 在社会上被击败的野生类型小鼠中,DA释放神经元活动的急性抑制逆转了社会厌恶.
结论:
- 存在一种神经元二分法,用于调节情绪与社会行为的调节,在不同的多巴胺神经元群体中由GR介导.
- 多巴胺感应神经元中的葡萄糖皮质体受体在压力诱导的社会厌恶中发挥关键作用.
- 激素基因作为应激弹性和多巴胺基调的调节之间的关键联系,影响社会行为.
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