运动训练与抗高血压药物治疗相结合. 对脂质,血压和左心室质量的影响
M H Kelemen1, M B Effron, S A Valenti
1Department of Medicine, Columbia Medical Plan, Md 21045.
JAMA
|May 23, 1990
概括
运动和抗高血压药物为血压提供了联合益处,但甲醇阻碍了运动诱导的胆固醇改善. 运动训练对高血压男性的左心室没有负面影响.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压的管理往往涉及药物治疗和生活方式的修改.
- 运动和抗高血压药物对心血管健康标志物的联合作用需要进一步研究.
研究的目的:
- 为了确定是否将运动与抗高血压药物相结合,可以提供附加的血压益处.
- 评估药物治疗是否影响运动诱导的脂质配置文件的改善.
- 评估运动训练对高血压男性左心室结构和功能的影响.
主要方法:
- 52名高血压男性被随机分配给接受diltiazem,propranolol或安慰剂.
- 参与者参加了为期10周的炼计划,包括举重训练和步行/慢跑.
- 评估了血压,脂质概况和左心室质量/透缩功能.
主要成果:
- 运动训练在所有组都降低了血压.
- 在所有组中,总和LDL胆固醇随着运动而降低.
- 随着安慰剂和diltiazem的使用,HDL胆固醇得到改善,但与propranolol没有改善.
- 左心室质量增加,而透缩功能在运动时保持不变.
结论:
- 除了运动之外,抗高血压药物治疗没有提供额外的血压降低.
- 普罗巴诺洛尔限制了HDL胆固醇中运动诱导的有益变化.
- 在这个队列中,运动训练并没有对左心室结构或扩张功能产生不利影响.
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