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Published on: July 2, 2020
为了有利于在食物短缺的情况下生存,大脑会禁用昂贵的记忆
Pierre-Yves Plaçais1, Thomas Preat
1Genes and Dynamics of Memory Systems, Neurobiology Unit, UMR 7637 École Supérieure de Physique et de Chimie Industrielles/CNRS, 10 rue Vauquelin, 75005 Paris, France.
概括
饥饿的果使昂贵的长期记忆 (LTM) 形成失效,以节省能量和提高生存率. 这种适应性大脑可塑性在食物短缺期间优先考虑生命而不是记忆.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 生理学 生理学 生理学
背景情况:
- 大脑是调节能量平衡的核心.
- 在资源稀缺期间,大脑优先考虑其能源供应,而不是外围器官.
- 目前尚不清楚大脑是否能够减少自身的能量消耗以提高生存率.
研究的目的:
- 为了研究大脑是否可以降低能量消耗以有利于生存.
- 为了检查饥饿对大脑功能的影响,特别是多索菲拉的记忆形成.
主要方法:
- 在饥饿条件下研究了Drosophila melanogaster.
- 研究了厌恶性长期记忆 (LTM) 的形成及其神经支.
- 利用神经电路分析,专注于多巴胺基神经元及其活动模式.
- 使用特定神经元的暂时人工激活来评估LTM恢复和生存权衡.
主要成果:
- 果虫的饥饿特别抑制了昂贵的厌恶性长期记忆 (LTM) 的形成.
- 这种生理状态对于食欲的LTM形成是必要的.
- 多巴氨基神经元的缓慢振荡,对于厌恶的LTM至关重要,在饥饿的中被废除了.
- 这些神经元的人工激活恢复了LTM,但降低了生存率.
结论:
- 大脑的能量消耗被适应性调节,以促进饥饿期间的生存.
- 在食物短缺下,厌恶性长期记忆 (LTM) 的形成被抑制,作为一种适应机制.
- 这表明LTM形成的可塑性优先考虑了生物的生存.
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