通过模块化控制转录因子转位的调制信号处理
Nan Hao1, Bogdan A Budnik, Jeremy Gunawardena
1Harvard University Faculty of Arts and Sciences Center for Systems Biology, Cambridge, MA 02138, USA.
Science (New York, N.Y.)
|January 26, 2013
概括
酵母中的转录因子Msn2充当可调节的信号处理器,通过核运输的双重调节,调整其功能以适应不同的压力信号. 这允许对环境变化做出多样化的反应.
科学领域:
- 分子生物学分子生物学
- 细胞信号传输 细胞信号传输
- 系统生物学 系统生物学
背景情况:
- 信号通路产生不同的转录因子 (TF) 激活动态.
- 了解TF如何处理信号以产生各种响应至关重要.
研究的目的:
- 研究转录因子如何处理信号输入以产生各种动态反应.
- 阐明酵母TF Msn2.2中可调节信号处理的机制.
主要方法:
- 在芽酵母中研究了一般应激反应的TF Msn2.
- 分析了响应信号输入的TF激活动态.
- 通过酸化研究了双重监管 (核进出口) 的作用.
主要成果:
- Msn2 作为可调节的信号处理器,能够根据输入类型跟踪,过或集成信号.
- 突变分析显示,仅核进出口的监管就将 Msn2 限制在单个信号处理功能上.
- 通过酸化的双调节使Msn2能够实现多功能信号处理.
结论:
- Msn2可调节的信号处理对于产生对各种自然压力的独特动态反应至关重要.
- 复杂的信号处理功能可以在单个分子中集成.
- 这些发现指导了具有"可编程"信号处理能力的TF的设计.
相关概念视频
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02:16Transcription Factors
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