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Updated: May 14, 2026

Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
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芳香的硫尼尔化物共振地动力稳定了transthyretin,以防止amyloidogenesis,同时提供光结合物

Neil P Grimster1, Stephen Connelly, Aleksandra Baranczak

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|January 29, 2013
PubMed
概括

研究人员开发了新型的1,3,4-oxadiazoles,可以选择性地结合转氨酸 (TTR) 并形成共价合物. 这些分子动态稳定了TTR,防止了粉样蛋白的形成,并为成像应用提供了潜在的可能性.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...