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识别早期复制的脆弱部位,这些部位有助于基因组的不稳定

Jacqueline H Barlow1, Robert B Faryabi, Elsa Callén

  • 1Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

Cell
|January 29, 2013
PubMed
概括

研究人员在B细胞中发现了早期复制脆弱部位 (ERFS),即早期DNA复制过程中发生的DNA双链断裂 (DSB). 这些部位与基因组不稳定性和癌症发展有关.

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