响应生物模拟网络来自聚氨酸液凝
Paul H J Kouwer1, Matthieu Koepf, Vincent A A Le Sage
1Radboud University Nijmegen, Institute for Molecules and Materials, Department of Molecular Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. p.kouwer@science.ru.nl
Nature
|January 29, 2013
概括
研究人员开发了模仿生物组织的合成凝. 这些新的聚酸凝表现出应力强化,为先进应用提供了一种新的仿生材料.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 细胞力学 细胞力学
背景情况:
- 生物系统依赖于机械反应能力,由像actin和collagen这样的蛋白质控制.
- 这些蛋白质形成螺旋结构,产生具有不同机械性质的材料.
- 细胞骨蛋白质凝表现出应力强化,这种特性以前没有在合成凝中复制.
研究的目的:
- 创建合成凝,复制中间线丝凝的机械性能.
- 为了研究分子结构和合成凝中的大量机械行为之间的关系.
- 为潜在的生物医学应用开发功能生物仿真水凝.
主要方法:
- 合成了与oligo ((乙烯基醇) 侧链接接种的多酸盐.
- 使用宏观风湿学,原子力显微镜和分子力光谱学进行表征.
- 理论网络模型的应用,将单分子特性与散装力学联系起来.
主要成果:
- 合成凝在机械反应中模仿中间丝凝,包括应力硬化.
- 一个可调节的热过渡会诱导聚合物捆绑,在非常低的度下形成透明的凝.
- 建立了单分子参数 (刚性,捆绑) 和散装机械性质之间的等级联系.
结论:
- 分子刚度和捆绑程度都对开发人工细胞骨或细胞外基质模拟器至关重要.
- 聚化聚合物为创建功能生物仿真水凝提供了一个多功能平台.
- 这些材料有望用于各种应用,特别是在生物医学领域.
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