相关实验视频
Updated: May 13, 2026
12:59
BEST: Barcode Enabled Sequencing of Tetrads
Published on: May 1, 2014
在酵母交叉中找到遗传能力缺失的来源
Joshua S Bloom1, Ian M Ehrenreich, Wesley T Loo
1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA.
Nature
|February 5, 2013
概括
研究人员研究了酵母,以了解特征中的"缺失遗传性". 他们发现检测到的基因位置解释了大多数遗传变异,基因相互作用的作用比预期的要小.
科学领域:
- 遗传学 是一个遗传学.
- 量化生物学 量化生物学
- 酵母遗传学 酵母遗传学
背景情况:
- 这是一个很棒的节目,这是一个很棒的节目.
- 缺失的遗传性 缺失的遗传性
- 这个问题是指从家族研究中估计的遗传性与许多特征 (包括人类疾病) 的确定的遗传位点解释的变异之间的差距.
研究的目的:
- 准确估计定量特征遗传变异的来源.
- 以高的统计能力来检测潜在的基因位置.
- 研究基因相互作用对遗传性的贡献.
主要方法:
- 使用了两种不同的酵母菌株之间的大型交叉.
- 分析了46个定量特征,以评估遗传变异.
- 采用高统计功率方法进行位置检测和相互作用分析.
主要成果:
- 检测到的基因位点解释了几乎整个添加剂对研究特征的遗传变异的贡献.
- 基因-基因相互作用对遗传性的贡献在特征之间有很大差异,从微不足道到大约50%.
- 确定的两位点相互作用只占总相互作用遗传性的很小一部分.
结论:
- 这项研究显著提高了对遗传性缺失问题的理解.
- 来自检测到的基因位点的附加遗传效应是这些特征遗传变异的主要驱动因素.
- 基因与基因相互作用的贡献是可变的,但并不是以前无法解释的遗传性的唯一解释.
相关概念视频
01:20Monohybrid Crosses
Overview
01:18Dihybrid Crosses
Overview
01:49Hardy-Weinberg Principle
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
01:20Monohybrid Crosses
Overview
02:27Trihybrid Crosses
Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...
02:46Chi-square Analysis
The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an observed value. In the context of genetics, it enables us to either accept or reject a hypothesis, based on how much the observed values deviate from the expected values.
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...