怀孕期间血压升高和随后的慢性疾病风险
Tuija Männistö1, Pauline Mendola, Marja Vääräsmäki
1Division of Epidemiology, Statistics and Prevention Research, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child, Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA. mannistoTI@mail.nih.gov
Circulation
|February 13, 2013
概括
妊娠高血压,包括妊娠高血压,显著增加了心血管疾病,脏疾病和糖尿病的长期风险. 早期监测和干预对受影响的妇女至关重要.
科学领域:
- 心血管流行病学心血管流行病学
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 孕前是一种已知的未来心血管疾病的风险因素.
- 关于与其他形式的妊娠相关高血压相关的心血管风险的数据有限.
研究的目的:
- 研究怀孕期间各种类型的高血压后心血管疾病,脏疾病和糖尿病的长期风险.
主要方法:
- 利用了1966年北芬兰出生队列 (N=10,314名女性) 的数据.
- 从产前记录和问卷收集了怀孕期间血压的前性数据.
- 通过芬兰登记处确定后续诊断,平均随访时间为39.4年.
- 雇员调整的危险比率 (HRs) 用于比较高血压和正常血压妇女之间的风险.
主要成果:
- 怀孕期间的高血压,无论类型如何,都与随后心血管疾病和动脉高血压的风险增加有关.
- 孕期高血压增加了缺血性心脏病,心肌梗塞,心力衰竭,缺血性中风,脏病和糖尿病的风险.
- 鉴定了孤立的静脉缩和静脉缩高血压的特定风险,包括心肌梗塞死亡和缺血性心脏病.
结论:
- 怀孕期间血压升高是未来心血管疾病,慢性病和糖尿病风险高的强有力的指标.
- 即使没有已知的危险因素,这些风险仍然存在.
- 临床监测,风险因素评估和及时干预建议妇女与妊娠相关的高血压.
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