细菌氧化可以延长C. elegans的寿命
Ivan Gusarov1, Laurent Gautier, Olga Smolentseva
1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Cell
|February 19, 2013
概括
细菌衍生的氧化 (NO) 延长了圆虫Caenorhabditis elegans的寿命和抗压能力. 这种物种间的信号突出显示了共生细菌对宿主的终身益处.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 微生物学 微生物学
背景情况:
- 氧化 (NO) 是动物中至关重要的信号分子,通常由NO合成酶 (NOSes) 合成.
- 圆虫Caenorhabditis elegans缺乏内源的NOS酶,为研究NO信号提供了一个独特的模型.
- C. elegans自然消耗细菌,其中一些具有功能性的NOS.
研究的目的:
- 调查细菌衍生的NO在C. elegans中的作用.
- 确定NO对C. elegans长寿和抗压能力影响的分子机制.
主要方法:
- 用表达功能性NOS的细菌养C.elegans.
- 评估C. elegans的长寿和抗压现象型.
- 分析基因表达模式和转录因子参与 (HSF-1,DAF-16).
主要成果:
- 细菌NO显著提高了C. elegans的寿命.
- 细菌NO提高了C. elegans对压力的抵抗力.
- 观察到的效应是由HSF-1和DAF-16转录因子调节的特定基因组调节的.
结论:
- 细菌NO作为一种物种间信号分子,有利于宿主C. elegans.
- 交叉体细菌通过诸如NO信号等机制,为它们的宿主提供终身的优势.
- 这项研究揭示了在C. elegans中NO介导寿命延长和应激适应的新途径.
相关概念视频
Nitric Oxide Signaling Pathway
6.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.2K
Oxidation Numbers
42.3K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.3K
Pyruvate Oxidation
168.5K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.5K
Oxidation-Reduction Reactions
75.3K
Oxidation–Reduction Reactions
75.3K
Gravitational Potential Energy for Extended Objects
1.9K
Consider a system comprising several point masses. The coordinates of the center of mass for this system can be expressed as the summation of the product of each mass and its position vector divided by the total mass:
1.9K
Bacterial Signaling
40.4K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.4K


