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除了二次结构之外:主要序列决定因素授权pri-miRNA发针进行处理

Vincent C Auyeung1, Igor Ulitsky, Sean E McGeary

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Cell
|February 19, 2013
PubMed
概括

科学家在初级microRNA (pri-miRNAs) 中确定了关键序列元素,这些元素对于它们的处理是必要的. 这些决定因素使人体细胞能够区分功能性primiRNA与其他毛RNA,确保适当的microRNA生产.

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...