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Updated: Feb 2, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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激活RNA与调解器结合,以增强染色体结构和转录

Fan Lai1, Ulf A Orom, Matteo Cesaroni

  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

Nature
|February 19, 2013
PubMed
概括

激活长非编码RNAs (lncRNAs) 招募中介复合体来激活邻近的基因. 这种相互作用对基因调节至关重要,并且在疾病中受损,突出显示了中介在ncRNA-a功能中的作用.

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