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Updated: May 14, 2026

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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精确的RNA聚合酶地图揭示了促进者如何直接启动和暂停

Hojoong Kwak1, Nicholas J Fuda, Leighton J Core

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

Science (New York, N.Y.)
|February 23, 2013
PubMed
概括

RNA聚合酶II (Pol II) 在促进体中暂停是转录调节的关键. 新的PRO-seq方法揭示了核心促进元素集体地决定了暂停位置和强度,挑战了固定的模型.

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RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
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