捐赠人脑死亡加剧了移植心脏中补充依赖性缺血/再损伤
Carl Atkinson1, Bernhard Floerchinger, Fei Qiao
1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
Circulation
|February 28, 2013
概括
大脑死亡 (BD) 恶化了心脏移植损伤和排斥. 补充抑制疗法在BD和活体供体心脏中显著降低了这种损伤,提供了一个潜在的治疗策略.
科学领域:
- 移植免疫学 移植免疫学
- 心血管研究研究心血管研究
- 器官的保存 器官的保存
背景情况:
- 大脑死亡 (BD) 可能导致主要的捐赠器官,增加移植后缺血/再输液 (I/R) 损伤.
- 用一种新的BD小鼠模型来研究其对心脏I/R损伤的影响.
研究的目的:
- 研究捐赠者BD对心脏I/R移植后损伤的影响.
- 评估补充剂抑制剂在接受BD供体心脏的患者中的治疗潜力.
- 使用人类心脏活检评估临床相关性.
主要方法:
- 从活体或BD供体小鼠移植到接受者的心脏.
- 使用补充抑制剂CR2-Crry或车辆控制.
- 分析了针对损伤,炎症,补充体沉积和生存的小鼠异位移植/异位移植.
- 检查了人类心脏活检,以检查补体沉积和炎症.
主要成果:
- 捐赠者BD显著加剧心脏I / R损伤和小鼠中的异种移植排斥.
- CR2-Crry治疗显著减少了来自BD和活体供体的移植中的损伤,炎症和补充沉积.
- 人体活检证实了BD供体移植中加剧的补体沉积和炎症.
结论:
- 大脑死亡加剧了心脏I / R损伤,并降低了老鼠和人类的异种移植存活率.
- 有针对性的补充抑制有效地改善了与BD相关的I / R损伤.
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