客人包装图案在一个超分子纳米和一个共价模拟的纳米
Simin Liu1, David H Russell, Nathanael F Zinnel
1Department of Chemistry, Tulane University, New Orleans, Louisiana 70115, USA.
Journal of the American Chemical Society
|March 2, 2013
概括
八酸和六酸二胺结合的八酸宿主是复杂的n-基. 根据客人大小和主机属性观察到不同的客人包装动机,揭示了不同的组装行为.
科学领域:
- 超分子化学 超分子化学
- 主机和客人的化学反应
背景情况:
- 疏水效应是分子自我组装和封装的关键驱动力.
- 八酸 (OA) 和六二胺结合的八酸 (HOA) 是合成宿主,能够形成包容复合体.
研究的目的:
- 为了研究OA和HOA宿主对n-基的封装.
- 阐明客人的包装模式及其依赖于客人的尺寸和主机结构.
- 为了比较OA和HOA的组装特性和包装模式配置文件.
主要方法:
- 核磁共振 (NMR) 谱学,包括1H NMR,NMR扩散,COSY和NOESY实验.
- 使用一系列n-基到n-hexacosane (C26H54) 的复杂化研究.
主要成果:
- 无论是OA还是HOA,都成功地复合了广泛的n-基.
- 确定了四种不同的客人包装模式,受客人规模和主机类型的影响.
- 随着客人体积的增加,观察到动图之间的平滑过渡,从而可以进行稳定性比较.
- 尽管封装环境相似,但OA和HOA由于组装属性的变化而表现出不同的包装模式.
结论:
- 这项研究表明,OA和HOA具有与n-基一起形成纳入复合物的能力.
- 客人包装和主机组装属性显著影响观察到的图案及其过渡.
- 这些发现提供了对结构-属性关系的洞察,这些关系控制了超分子化学中的宿主-客人相互作用.
相关概念视频
Noncovalent Attractions in Biomolecules
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Noncovalent Attractions in Biomolecules
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
Valence Bond Theory
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
DNA Packaging
Overview


