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Jmjd3通过上调INK4a/Arf的表达来抑制重编程,并针对PHF20进行无处不在

Wei Zhao1, Qingtian Li, Stephen Ayers

  • 1Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, TX 77030, USA.

Cell
|March 5, 2013
PubMed
概括

Jmjd3负面调节细胞重编程,使其成为诱导多能干细胞 (iPSC). 它的缺席增强了iPSC的产生,而它的存在则抑制了它,揭示了一个新的Jmjd3-PHF20监管轴.

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