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Updated: May 2, 2026

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
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自细胞在ER-线粒体接触点形成

Maho Hamasaki1, Nobumichi Furuta, Atsushi Matsuda

  • 1Department of Genetics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Nature
|March 5, 2013
PubMed
概括

细胞回收过程中至关重要的自细胞源于哺乳动物细胞的内网膜-线粒体接触部位. 这一发现澄清了细胞平衡过程中自细胞形成的膜起源.

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Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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