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多功能信封型半孔化纳米颗粒用于瘤触发的向药物输送
Jing Zhang1, Zhe-Fan Yuan, Ya Wang
1Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University , Wuhan 430072, P. R. China.
Journal of the American Chemical Society
|March 8, 2013
概括
一种新型的多功能纳米粒子保护药物免受正常细胞的影响,并向癌细胞. 它在瘤内部释放药物,由谷氨触发,增强向癌症治疗.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 开发有针对性的药物输送系统对于提高癌症治疗疗效和减少副作用至关重要.
- 半孔纳米颗粒为药物封装和控制释放提供了一个多功能平台.
- 瘤微环境为刺激反应药物释放提供了独特的点.
研究的目的:
- 设计和合成一种新型的多功能信封型半孔化纳米粒子 (MEMSN),用于瘤触发的药物输送.
- 在正常细胞中实现细胞吸收屏蔽,并在瘤细胞中实现活跃向.
- 为了使癌细胞内由谷氨触发的细胞内药物释放.
主要方法:
- 用β-环氧化 (通过二硫化链) 和RGD/MMP基质 (通过宿主-客人相互作用) 修饰半孔性二氧化纳米粒子的表面.
- 用聚酸 (PASP) 装饰,以创建一个屏蔽层,以防止正常细胞吸收.
- 在体外评估细胞吸收,向效率和药物释放机制,在存在矩阵金属蛋白酶 (MMP) 和谷氨 (GSH) 的情况下.
主要成果:
- MEMSN证明了有效的屏蔽,防止正常细胞吸收.
- 在富含MMP的环境中,成功去除了PASP屏蔽层,暴露了瘤细胞的向配体.
- 观察到瘤细胞增强细胞吸收,随后通过谷氨调解的细胞内药物释放.
- 多功能纳米粒子表现出瘤特异性向和受控的药物释放特性.
结论:
- 设计的MEMSN有效地屏蔽了正常细胞的有效载荷,并实现了瘤特异性向.
- 双响应系统 (MMP和GSH) 能够有效地输送药物和在癌细胞中的细胞内释放.
- 这种新的纳米粒子平台对先进的癌症治疗有很大的潜力.
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